改善免疫疗法中神经毒性的检测
授予资金高达$ 200,000，$ 125,000和75,000美元
Overview
有新的免疫疗法cancer treatments可用于血液系统恶性肿瘤，例如基于T细胞的免疫疗法和嵌合抗原受体T细胞（CAR-T）疗法。但是，有些患者experience neurotoxicityas a result of treatment.Clinical symptoms or signs可以是进步的，可能包括失语症，意识水平改变，认知技能障碍，运动弱点，癫痫发作和脑水肿。
尽管有时严重，但神经毒性主要是可逆的，可以通过专门的患者监测和护理来检测。急性毒性的早期检测可能会导致早期干预，并最终导致患者的预后改善。例如，research分析表明,病人的笔迹aid in identifying neurotoxicity prior to the presentation of other noticeable symptoms.
To inspire early identification of neurotoxicity, Johnson & Johnson Innovation, together with Janssen Global Services, is proud to launch the改善免疫疗法中神经毒性的检测QuickFire Challenge。Visionaries are invited to submit methods and technologies aiming to optimize patient care for immunotherapies within the hematologic malignancy space by enabling early detection of neurotoxic events. Of particular interest are technologies aiming to identify clinical manifestations to predict acute toxicities, including movement and neurocognitive disorders.
The innovator(s) with the best potential solution can receive grant funding in increments up to $200,000, $125,000, or $75,000, access to the global Johnson & Johnson Innovation – JLABS network and mentorship from experts at the Johnson & Johnson Family of Companies (‘Johnson & Johnson’).*
* Subject to the execution of the necessary documentation and (award) agreements.
Why this challenge matters to us
在Johnson＆Johnson Innovation，我们的信条激发了我们将我们服务的人们的需求和福祉。共同努力，我们可以激发下一个好主意，该主意可能会改变世界各地患者的健康轨迹。
我们在寻找什么
Visionaries are invited to submit methods and technologies aiming to optimize patient care for immunotherapies within the hematologic malignancy space by enabling early detection of neurotoxic events. Of particular interest are technologies aiming to identify clinical manifestations to predict acute toxicities, including movement and neurocognitive disorders.
标准
潜在的解决方案将由审阅者和法官的独立小组评估其满足以下标准的能力：
- Accuracy in detecting and characterizing clinical manifestations, with a specific interest in variations in handwriting including micrographia, dysgraphia, and agraphia
- 患者可访问性
- 无缝集成到医疗机构和现有的患者护理模型中
- 可行性和部署计划
- Potential impact
奖项
- 授予资金高达$ 200,000，$ 125,000和75,000美元
- Access to the global Johnson & Johnson Innovation - JLABS (‘JLABS’) network
- 导师ship from experts across the Johnson & Johnson Family of Companies (‘Johnson & Johnson’)*
常见问题解答
如果我在访问门户网站时遇到麻烦怎么办？
确保您的浏览器是最新的，并接受cookie。您可以通过[email protected]if you are having technical difficulties as well.
Can I submit supporting documents (for example a video) as part of my application?
You will have the opportunity and are encouraged to upload supporting materials such as non-confidential slide decks, research papers, and videos as part of your application. You may submit a video along with your typed responses. Maximum length is 2 minutes. Make sure that you do not submit any information that is non-proprietary or owned by a third party.
如果我提交的一些信息是机密的，可以吗？
不要提交机密信息。仅应提交非固定信息，并且您提交的任何内容都将被视为非机密。
What happens with IP (Intellectual Property)?
由于这是一个没有连接的字符串的安排，因此JLABS不会获得任何IP。任何IP创建和/或保护仍然是发明者的唯一责任。
是否需要申请专利？
No, a patent is not required to apply. However, you should not submit any information that you wish to keep confidential or that may negatively impact the future patentability of your invention, or that is被认为是商业秘密或特权。
What kind of science / technology is appropriate for the Challenges?
We encourage all to apply. Find out more about what areas we desire to explore here:https://www.jnjinnovation.com/partnering
Who is eligible to apply?
每个挑战都有我们要求您接受的条款和条件，可以在填写申请之前找到。
您对哪个创新阶段感兴趣？
We are interested in tangible innovations at a variety of stages – including ideation, prototyping, piloting, and commercial launches. Submissions should align to our areas of focus and not be limited to academic research projects.
What are the specific criteria for application?
潜在的解决方案将由审稿人和法官的小组评估其满足以下标准的能力：
- Accuracy in detecting and characterizing clinical manifestations, with a specific interest in variations in handwriting including micrographia, dysgraphia, and agraphia
- 患者可访问性
- 无缝集成到医疗机构和现有的患者护理模型中
- 可行性和部署计划
- Potential impact
如果我对挑战或申请过程有疑问，我可以联系谁？
请联系[email protected]with any questions.
我在哪里申请？我必须一次坐下来完成申请吗？
You can setup an account athttps://jnjquickfire.secure-platform.com。You are able to save your work and log back in to finish at a later time if needed.
您感兴趣的是什么类型的想法？
提交应该有商业化的途径。虽然想法可能是早期，但我们并不是在寻找研究项目not pursuing a可行的潜在解决方案。
如何利用授予资金？
要求申请人详细说明他们对资金作为Quickfire挑战申请的一部分的预期使用，以及他们如何预期资金将加速其解决方案，以实现其应用程序中概述的里程碑。赠款资金必须仅用于QuickFire Challenge应用程序中所述的创新解决方案的合法进步。为了避免疑问，以下是赠款资金不可避免的用途清单：
- 砖和砂浆成本
- 游说，包括但不限于基层游说
- 医疗服务的规定（例如，通过远程医疗服务进行直接患者参与）
- 将穿越到医疗保健提供者和/或政府官员/雇员（例如，用于HCP的薪水）
- 向过去的开发活动支付（例如支付商业贷款）
没有特定的费率或百分比在开销等方面允许或不允许。也就是说，所有申请均可根据资金所产生的影响和里程碑成就进行评估。在裁决期结束时，需要一份进度报告，包括有关使用资金的详细信息。
时间线
关于约翰逊和约翰逊的詹森制药公司
At Janssen, we’re creating a future where disease is a thing of the past. We’re the Pharmaceutical Companies of Johnson & Johnson, working tirelessly to make that future a reality for patients everywhere by fighting sickness with science, improving access with ingenuity, and healing hopelessness with heart. We focus on areas of medicine where we can make the biggest difference: Cardiovascular & Metabolism, Immunology, Infectious Diseases & Vaccines, Neuroscience, Oncology, and Pulmonary Hypertension.
About Johnson & Johnson Innovation
Johnson & Johnson Innovation LLC works across the pharmaceutical, medical device and consumer health sectors to accelerate early-stage, transformational solutions by catalyzing the best ideas, wherever they are in the world. We do this by harnessing our deep scientific capabilities coupled with a wide range of tools, including customized deal structures, company creation, incubation and startup services, capital investments and other innovative business models that aim to meet the diverse needs of entrepreneurs, scientists and emerging companies. Our goal is to help life science and health technology innovations thrive through collaboration and partnership with the global ecosystem, so that together we can change the trajectory of human health. Meet our passionate team of science and technology experts and learn how to collaborate with us atwww.jnjinnovation.com。